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Research Level: Extensive Immune defense

Meshima.

Phellinus linteus

Medically reviewed by Dr. Irvine Russell, M.D.

Phellinus linteus is a perennial polypore fungus of the family Hymenochaetaceae, forming large, woody, hoof-shaped basidiocarps on the trunks of living and dead hardwood trees, particularly mulberry (Morus spp.). The fruiting body is characterized by a dark brown to black upper surface with concentric zonation, a golden-yellow to brown pore surface, and extremely hard, woody tissue. Known as Meshima (women's island) in Japan, Sang-Hwang in Korea, and Song Gen in China, it has been used in East Asian traditional medicine for centuries. P. linteus has become one of the most intensively studied medicinal mushrooms in East Asian oncology, with over 100 published studies documenting its immunomodulatory, anti-tumor, anti-inflammatory, and antioxidant properties, primarily attributed to hispolon (a polyphenol), proteoglycans, and high-molecular-weight polysaccharides.

#23

Popularity Rank

Extensive

Research Level

3

References

4

Key Compounds

Meshima
Main Compound

Hispolon

Dr. Irvine Russell, M.D.
Dr. Irvine Russell, M.D.

Board-Certified Physician · Medical Reviewer · Last Reviewed February 25, 2026

Key Takeaway

Meshima (Phellinus linteus) is a functional mushroom with a extensive level of scientific research supporting its use. Its primary bioactive compounds — Hispolon, Polysaccharides, Interfungins, and 1 others — have been studied for benefits including immune modulation, anti-cancer research, anti-inflammatory, antioxidant protection. Multiple human clinical trials have investigated Meshima, making it one of the most evidence-backed functional mushrooms available. Meshima is ranked #23 in popularity among functional mushroom species, with 3 cited research references in our database. The most commonly recommended form is hot water or dual extract. Typical supplemental dosages range from 500 mg to 3,000 mg per day depending on extract concentration and intended use.

SCIENCE OVERVIEW.

Evidence Grade: A

Meshima has been extensively studied in both preclinical and clinical research. Multiple human trials have investigated its potential benefits.

Key Insight

Meshima is a dark, woody bracket fungus that grows on mulberry trees and has become one of the most intensively researched medicinal mushrooms in the world, particularly in Japan and Korea. Its...

Traditional Use

Meshima has been used in traditional medicine systems for centuries, particularly in Traditional Chinese Medicine (TCM) and other Asian healing practices.

Historical Context: Traditional use does not guarantee efficacy or safety. Modern research is ongoing to validate traditional claims.

Meshima is a dark, woody bracket fungus that grows on mulberry trees and has become one of the most intensively researched medicinal mushrooms in the world, particularly in Japan and Korea. Its Japanese name, Meshima, means "women's island" — a reference to Meshima Island in Nagasaki Prefecture where the mushroom was traditionally harvested. In Korea, it is called Sang-Hwang and has been used for centuries as a traditional remedy for various ailments, particularly those related to immune function.

What sets Meshima apart from other medicinal mushrooms is the depth and focus of its research base. Over 100 published studies have investigated its properties, with particular attention to its immunomodulatory and anti-cancer potential. Korean and Japanese researchers have documented its ability to activate multiple arms of the immune system — macrophages, natural killer cells, T-cells, and dendritic cells — making it one of the most potent immune-stimulating mushrooms studied to date. Memorial Sloan Kettering Cancer Center maintains a dedicated monograph on Phellinus linteus, acknowledging the significant body of preclinical evidence.

Traditionally, Meshima was prized in Korean and Japanese folk medicine as a tonic for women's health and general vitality. Korean practitioners used it to support patients undergoing conventional medical treatments, and it remains widely used as a complementary health approach in East Asian countries. The mushroom's long history of safe use in traditional medicine has contributed to its acceptance in modern integrative health practices.

Meshima supplements are available primarily in capsule and extract form. Mushroom Wisdom (a well-known medicinal mushroom brand) sells dedicated Meshima products, and FreshCap lists Phellinus as one of its key mushroom species. The extract is also found in some premium multi-mushroom immune support formulas. Typical dosages range from 500 mg to 2,000 mg per day of standardized extract.

When selecting a Meshima supplement, look for products standardized to polysaccharide or beta-glucan content, as these are the primary bioactive compounds. Hot water extraction is the standard method for Meshima, as its woody fruiting body requires intensive processing to release the beneficial compounds. Products from reputable brands with third-party testing are recommended, as the mushroom's relative obscurity in Western markets means quality can vary significantly.

Meshima combines well with other immune-supporting mushrooms like turkey tail, maitake, and reishi for a comprehensive immune support protocol. Some practitioners recommend it alongside conventional health approaches, though it is important to consult with a healthcare provider before combining any supplement with medical treatments. While Meshima may not yet have the mainstream recognition of lion's mane or reishi, its research profile makes it one of the most scientifically compelling medicinal mushrooms available.

Meshima ELITE.

Top products containing verified Phellinus linteus extracts.

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SIMILAR SPECIES.

Medical Reviewer

Dr. Irvine Russell, M.D.
Dr. Irvine Russell, M.D.

Board-Certified Physician · Medical Reviewer

Board-certified physician affiliated with UC Irvine, the Gavin Herbert Eye Institute, and the UCI School of Medicine. Dr. Russell reviews all mushroom encyclopedia entries for scientific accuracy, ensuring claims are supported by peer-reviewed research.

Last reviewed: February 25, 2026

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